Bromantane
C16H20BrN
Research Use Only. Bromantane is a research compound intended strictly for laboratory and scientific research purposes. It is not approved for human consumption, therapeutic use, or veterinary use. Information on this page is provided for educational and research reference purposes only.
Overview
Bromantane is a synthetic compound with a unique bicyclic adamantane-based structure, developed originally in Russia and studied extensively in the context of adaptogen and actoprotector research. It belongs to a category of synthetic compounds sometimes classified as actoprotectors — a subset of adaptogens that have been explored in laboratory and experimental settings for their potential to influence physical performance and stress response mechanisms. Unlike plant-derived adaptogens such as those from ginseng or rhodiola, bromantane is entirely synthetic in origin, combining an adamantane backbone with a bromophenyl group to produce its distinct molecular profile. Research involving bromantane has appeared in studies examining how synthetic compounds may affect physiological stability under conditions such as hyperthermia, hypoxia, and physical exertion in animal models. Bromantane is intended strictly for research purposes and is not approved for human consumption or therapeutic use.
Compound Data
| CAS Number |
87913-26-6 |
| Molecular Formula |
C16H20BrN |
| Molecular Weight |
306.24 g/mol |
| IUPAC Name |
N-(4-bromophenyl)adamantan-2-amine |
| PubChem CID |
4660557
|
Research & Bioactivity
Bromantane, also referred to in the literature as ladasten or bromantan, has been studied in the context of adaptogenic and actoprotective activity — a class of research examining compounds that may influence the body's response to physical and environmental stress. Researchers have investigated its pharmacological profile in animal models, including studies involving mice exposed to conditions of hyperthermia, hypothermia, and hypoxia, where the focus has been on physical working capacity under extreme conditions. Studies have also examined bromantane alongside other synthetic adaptogens in comparative reviews of compounds thought to influence physiological resilience without proportional increases in oxygen consumption. In male rat models, research has investigated its effects on stress responses and reproductive physiology, including observations related to spermatogenesis and fertilization capacity under experimental stress conditions. Additional animal studies have examined its influence on sexual behavior and pairing activity in both male and female rats following acute and chronic administration protocols. Bromantane continues to appear in pharmacological literature as a reference compound in the broader study of actoprotectors and synthetic adaptogens, and all such investigations have been conducted in preclinical research settings.
Also Known As
- Bromantane
- 87913-26-6
- Bromantan
- bromontan
- N1ILS53XWK
- 2-bromophenyl-1-amino adamantane
- N-(4-Bromophenyl)tricyclo(3.3.1.13,7)decan-2-amine
- Tricyclo(3.3.1.13,7)decan-2-amine, N-(4-bromophenyl)-
- DTXSID40405333
- Tricyclo[3.3.1.13,7]decan-2-amine, N-(4-bromophenyl)-
- RefChem:121499
- DTXCID10356186
- Ladasten
- N-(4-bromophenyl)adamantan-2-amine
- N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE
Published Research
Plant Adaptogens-History and Future Perspectives.
Todorova V, Ivanov K, Delattre C, Nalbantova V, Karcheva-Bahchevanska D, et al. — 2021
Adaptogens are synthetic compounds (bromantane, levamisole, aphobazole, bemethyl, etc.) or plant extracts that have the ability to enhance the body's stability against physical loads without increasing oxygen consumption. Extracts from , , , , and are considered to be naturally occurring adaptogens and, in particular, plant adaptogens. The aim of this study is to evaluate the use of plant adaptogens in the past and now, as well as to outline the prospects of their future applications. The use of natural adaptogens by humans has a rich history-they are used in recovery from illness, physical weakness, memory impairment, and other conditions. About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body's resistance to stress and to improve physical endurance. Although now many people take plant adaptogens, the clinical trials on human are limited. The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection. In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.
[Experimental evaluation of actoprotective activity of nitrogen-containing heterocyclic compounds derivatives in extreme conditions].
Tsublova EG, Ivanova TG, Ivanova TN, Iasnetsov VV — 2013
In experiments on nonlinear male mice the ability of new derivatives of nitrogen-containing heterocyclic compounds to increase the physical working capacity in conditions of hyperthermia, hypothermia and acute normobaric hypoxia and hypercapnia has been investigated. It is established, that pyridine derivative IBHF-11 has more expressed positive action in the said conditions. It provided increase of the working capacity of animals at all kinds of extreme influence, and the value of positive action was comparable, and in conditions of acute normobaric hypoxia and hypercapnia exceeded those at the reference products bemitil and bromantan.
The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.
Oliynyk S, Oh S — 2012
Actoprotectors are preparations that enhance body stability against physical loads without increasing oxygen consumption or heat production. Or, in short, actoprotectors are synthetic adaptogens with a significant capacity to improve physical performance. This paper explores the history of actoprotectors'development, their pharmacological properties, mechanism of action, and practical application to the improvement of mental and physical performance. A brief summary of the clinico-pharmacological characteristics of the main representatives of this class (bemitil and bromantane) is provided. Some other synthesized compounds, and even natural ones such as ginseng, also are regarded as potential actoprotectors, and these are treated herein as well. Actoprotectors, owing to their wide-ranging pharmacological activities, high efficiency and safety, can be applied under either normal or extreme conditions.
[Effect of ladasten on reproduction function in male rats].
Khamidova TV, Chigirinskiĭ IuL, Morozov IS — 2005
The effect of ladasten (bromantan) on the development of emotional stress and reproduction activity was studied in male rats. Ladasten administration led to restoration of the stress-violated orientational reactions and body weight, activation of the spermatogenesis (increase in the number and mobility of spermatozoas), normalization of the fertilizing capacity of spermatozoas, and reduction in the loss of embryos.
[The effect of bromantan on the sexual behavior and conception in rats].
Kuzubova EA, Bugaeva LI, Spasov AA — 2004
The results of experiments on rats showed that the psychotropic drug bromantan affects the sexual behavior and pairing activity. A three-day treatment with bromantan (30 and 300 mg/kg, p.o.) predominantly increased the sexual proceptivity, whereas a chronic administration (for 2 months in males and 2 weeks in females) produced a dose-dependent increase in both proceptivity and receptivity. The observed effects are probably related to the dopamine-positive action of bromantan.