Nonapeptide-1
C61H87N15O9S
Research Use Only. Nonapeptide-1 is a research compound intended strictly for laboratory and scientific research purposes. It is not approved for human consumption, therapeutic use, or veterinary use. Information on this page is provided for educational and research reference purposes only.
Overview
Nonapeptide-1 is a synthetic nine-amino-acid peptide with the CAS number 158563-45-2, sometimes referred to in research literature as Melanostatine 5. It belongs to a category of peptides studied in relation to melanogenesis — the biological process by which pigment is produced in skin cells — and is of particular interest to researchers exploring the alpha-melanocyte-stimulating hormone (α-MSH) signaling pathway. Its structure is designed to interact with melanocortin receptors, making it a subject of investigation in studies focused on how pigmentation responses are regulated at a cellular level. Nonapeptide-1 has appeared in published research examining its potential as a carrier or conjugate molecule in nanoparticle delivery systems, as well as in studies on UV-induced skin pigmentation mechanisms. This peptide is intended strictly for laboratory and research purposes and is not approved for human use or consumption.
Compound Data
| CAS Number |
158563-45-2 |
| Molecular Formula |
C61H87N15O9S |
| Molecular Weight |
1,206.50 g/mol |
| IUPAC Name |
(2S)-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1-[(2S)-2-amino-4-methylsulfanylbutanoyl]pyrrolidine-2-carboxamide |
| PubChem CID |
10418849
|
Research & Bioactivity
Nonapeptide-1 is a synthetic peptide that researchers have studied primarily in the context of melanogenesis — the biological process by which melanin pigment is produced in skin cells. Studies have examined its interaction with the melanocortin 1 receptor (MC1R) and its role in modulating the alpha-melanocyte-stimulating hormone (α-MSH) signaling pathway, which is understood to regulate pigmentation responses in the skin. In vitro and formulation-based research has investigated nonapeptide-1 as a component in topical delivery systems, including studies exploring its conjugation with mesoporous silica nanoparticles to assess how it may influence the bioavailability and targeting of other compounds in skin-related research models. Research has also examined its potential relevance to UV-induced pigmentation responses, particularly in the context of photoaging and hyperpigmentation, areas that are actively studied using both cell-based and human subject models. A randomized controlled pilot study included nonapeptide-1 as part of a combination formulation evaluated in the context of melasma, a condition characterized by facial hyperpigmentation, further illustrating the range of pigmentation-focused research in which this peptide has appeared.
Also Known As
- Nonapeptide-1
- 158563-45-2
- Melanostatine 5
- White 05
- Nonapeptide-1 [INCI]
- L-Valinamide, L-methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-
- 64W45420K5
- UNII-64W45420K5
- Met-pro-phe-arg-trp-phe-lys-pro-val
- RefChem:202301
- H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
- MFCD00672435
- Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
- (Met5,pro6,d-phe7,d-trp9,phe10)-alpha-msh (5-13)
- Nonapeptide 1
Published Research
Optimization of Dielectric Material Improves Ionization Capability and Mass Range of Dielectric Barrier Discharge Ionization Mass Spectrometry.
Guan X, Wei C, Yan X, Zenobi R — 2025
Dielectric barrier discharge ionization (DBDI) for mass spectrometry (MS) is still limited in terms of the upper mass range, the polarity of compounds that can be readily ionized, and thus the sensitivity. In this study, we studied the influence of several parameters, including the geometry and nature of the electrode and dielectric materials, on the performance of a DBDI source. We found that the electrode material had almost no impact on the ionization capability of DBDI. With increasing dielectric constant ϵ of the dielectric material, an improved performance could be achieved in terms of the mass range of ionizable molecules, which was found to be solely dependent on the choice of dielectric material. Increasing the voltage had little effect on expanding the mass range but instead produced more fragment ions. We were also able to ionize more polar compounds: the detection of nonapeptide-1 and the tryptic fragments of human serum albumin (HSA) became possible using DBDI-MS with a high-ε dielectric. The Table of Contents graphic depicts that with an increasing permittivity dielectric improved performance can be achieved in terms of the mass range of ionizable molecules.
Enhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging.
Huang ZJ, Zhou XH, Wen WQ, Huang ZT, Xuan J, et al. — 2024
Epigallocatechin-3-gallate (EGCG), a catechin present in green tea, has been studied extensively for its potential as a cosmetic ingredient due to its various biological properties. However, the low stability and bioavailability of EGCG have hindered its effective utilization in cosmetic applications. This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG. MSNs can regulate the EGCG release and provide ultraviolet light (UV) protection to possess excellent photostability. Nonapeptide-1 exhibits melanin transfer interference properties and reduces the melanin content in treated skin areas. In vitro and in vivo results confirmed that the EGCG-loaded MSNs retained antioxidant properties, effectively scavenged the melanin and significantly reduced the deoxyribonucleic acid (DNA) damage in skin cells exposed to UV irradiation. The melanin inhibition rate is 5.22 times and the tyrosinase inhibition rate is 1.57 times that of free EGCG. The utilization of this innovative platform offers the potential for enhanced stability, controlled release, and targeted action of EGCG, thereby providing significant advantages for skin application.This delivery system combines the advantages of antioxidant, anti-aging, and anti-UV radiation properties, paving the way for the cosmetics development with improved efficacy and better performance in promoting skin health and appearance.
Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway.
Chen J, Li H, Liang B, Zhu H — 2022
INTRODUCTION: Ultraviolet (UV) irradiation is a major environmental factor affecting photoaging, which is characterized by skin wrinkle formation and hyperpigmentation. Although many factors are involved in the melanogenesis progress, UV is thought to play a major role in tanning. The pathway of α-melanocyte-stimulating hormone (α-MSH)-melanocortin receptor 1 (MC1R) is associated with UV-induced melanogenesis. Thus, α-MSH antagonists may have applications in the prevention of melanogenesis. AIM: To investigate the effects of tea polyphenols (TPS) on pigmentation, and further explore the underlying mechanism. MATERIAL AND METHODS: Human keratinocyte cell line (HaCaT) cells and Human epidermal melanocytes (HEM) were exposed to UVA and treated with different concentrations of TPS or Nonapeptide-1 acetate salt (N-1A). Then, cell viability, melanin content, and tyrosinase activity of both kinds of cells were detected. Quantification of α-MSH in HaCaT cells and HEM cells determined by ELISA assays. Immunohistochemistry of HEM cells was employed to further investigate the expression of melanogenesis-related proteins. RESULTS: The different concentrations of TPS were found to decrease the melanin content, tyrosinase activity and melanogenesis-related proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase-related protein (TRP)1, and TRP2. Besides, TPS inhibited α-MSH-MC1R signalling through directly suppressed α-MSH expression rather than the down-regulated expression level of MC1R. CONCLUSIONS: Our findings indicate that TPS may be a potential whitening agent for use in cosmetics and the medical treatment of hyperpigmentation disorders.
A randomized controlled pilot study of a proprietary combination versus sunscreen in melasma maintenance.
Chatterjee M, Neema S, Rajput GR — 2021
BACKGROUND: Melasma is the commonest cause of facial hypermelanosis in skin type IV-VI. First-line treatment includes a triple combination containing topical corticosteroid and hydroquinone which have side effects on prolonged use. Chemical peels are a second-line management option with the laser being used in refractory cases, but the worsening of hyperpigmentation in darker skin types can occur following laser therapy. Sunscreen is a must to prevent relapses. AIMS AND OBJECTIVES: (i) To compare the effects of treatment with a proprietary combination (phenyl ethyl resorcinol, nonapeptide-1, aminoethyl phosphinic acid, antioxidants and sunscreen) versus sunscreen alone in limiting or reducing, melasma and preventing recurrence as a maintenance regimen after the initial use of triple combination,(ii) to evaluate the safety of the formulation studied, and (iii) to study the improvement of the quality of life of the patients after using the study formulation versus placebo. METHODS: It was a prospective double-blinded parallel-group randomized controlled pilot study. A total of 46 subjects were recruited by consecutive sampling methods and randomized to 23 each in case and control groups. The study period was eight months with three phases. Phase 1 constituted the application of triple combination for eight weeks by both groups followed by phase 2 with the case group applying proprietary medicine and the control group applying sunscreen. Phase 3 was a follow-up period to see the sustenance of results in both groups as well as any evidence of relapses. Sunscreen was applied in all three phases. RESULTS: Case group in the study showed improvement in the melasma severity score and mean melanin index as measured by mexameter but it did not attain statistical significance as compared to the control group. The melasma area and severity index score showed a consistent reduction in the case group, whereas it increased in the control group from baseline. LIMITATIONS: Small sample size and a short follow-up period of our study were major limitations. CONCLUSION: The proprietary combination, which has sunscreen as one of its constituents, is more effective in maintaining remission after triple combination without any added inconvenience of application of two separate preparations as compared to sunscreen alone.