Prostamax
C20H33N5O9
Research Use Only. Prostamax is a research compound intended strictly for laboratory and scientific research purposes. It is not approved for human consumption, therapeutic use, or veterinary use. Information on this page is provided for educational and research reference purposes only.
Overview
Prostamax is a synthetic short-chain tetrapeptide with the amino acid sequence Lys-Glu-Asp-Pro, belonging to a class of compounds known as oligopeptide bioregulators or epigenetic peptides. It is structurally related to peptides identified in various tissues and has been of interest to researchers exploring how small peptide sequences may interact with chromatin — the tightly wound complex of DNA and proteins found in cell nuclei. As an epigenetic regulator, it falls within a broader category of bioactive peptides studied for their potential influence on gene expression and cellular aging processes at the molecular level. Published research has examined Prostamax in the context of chromosome behavior, chromatin structure in lymphocyte cultures, and its presence in proteins associated with longevity in certain animal models. Prostamax is intended strictly for laboratory and research purposes and is not approved for human use or consumption.
Compound Data
| CAS Number |
473578-47-1 |
| Molecular Formula |
C20H33N5O9 |
| Molecular Weight |
487.50 g/mol |
| IUPAC Name |
(2S)-1-[(2S)-3-carboxy-2-[[(2S)-4-carboxy-2-[[(2S)-2,6-diaminohexanoyl]amino]butanoyl]amino]propanoyl]pyrrolidine-2-carboxylic acid |
| PubChem CID |
9848296
|
Research & Bioactivity
Prostamax (Lys-Glu-Asp-Pro) is a short-chain tetrapeptide that researchers have studied primarily in the context of chromatin structure, epigenetic regulation, and cellular aging. In vitro studies using human blood lymphocytes have examined how this peptide influences chromatin organization, with microcalorimetric analyses suggesting it may alter the thermal denaturation properties of chromatin, indicating changes in heterochromatin structure at the molecular level. Research has investigated its potential role as an epigenetic bioregulator, with studies noting that related short-chain peptides have been identified within proteins of long-lived species such as the naked mole rat, prompting interest in their broader biological significance. Organotypic tissue culture studies conducted in both young and aged rats have examined the tissue-specific effects of Prostamax alongside structurally similar peptides, observing responses in prostatic gland tissue explants at very low concentrations. Additionally, researchers have studied how Prostamax interacts with chromatin in the presence of heavy metal ions such as copper and cadmium, exploring how it may influence chromosomal characteristics including sister chromatid exchange frequency and nucleolar organizer regions in cells from aged donors. These findings have been generated exclusively through laboratory and animal model research, and all investigations have been conducted in preclinical settings.
Also Known As
- Prostamax
- SCHEMBL6660498
- EX-A10561
- 473578-47-1
Published Research
Peptides (Epigenetic Regulators) in the Structure of Rodents with a Long and Short Lifespan.
Khavinson VK, Kormilets DY, Mar'yanovich AT — 2017
We have discovered motives of short-chain epigenetically active peptides in some proteins of long-lived African mole rat Heterocephalus glaber. These epigenetic regulators are located in the protein structure between lysine and arginine residues, thus facilitating their release in limited proteolysis. Some of these epigenetic regulators are not found in the proteins of short-lived species - Norway rat Rattus norvegicus and house mouse Mus musculus.
[Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)].
Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN, Baratashvili NA, Lezhava TA — 2012
In this work is presented the data on the variability of the functional characteristics of the chromosomes in the cells exposed by oligopeptide bioregulator - Prostamax from old individuals (75-86 years). Evaluated: the frequency of sister chromatid exchanges (SCE); Ag-positive NORs (in associations and nonassociations), as well as the variability of the structural C-pericentromeric heterochromatin. Prostamax changed the chromosomal parameters: 1) increased the frequency of SCE to 12,0±0,28 exchange in per cell (in intact cells - 5,9±0,2); 2) increased the frequency of Ag-positive NORs to 2.5 per cell (in intact cells - 0.95) 3) reduced in the frequency of large segments of the options from the pericentromeric heterochromatin for the 1st and 9th chromosomes. Comparison of the results indicates the ability of Prostamax to decondensation, deheterchromatinization the chromatin during aging, and thus release by heterochromatinization repressed genes. On the other hand, the data obtained in this work suggest that the basis for the protective action of Prostamax its modifying effect on chromatin.
Microcalorimetric study of human blood lymphocytes culture at presence of copper, cadmium and prostamax.
Kiladze M, Gorgoshidze M, Monaselidze J, Jokhadze T, Lezhava T — 2009
Research goal was study of separate and joint influence of bioregulator prostamax and Cu(II) and Cd(II) ions on the chromatin structure in situ. The thermal characteristics of the denaturation process of blood lymphocytes culture of aging people in the presence of some microg quantities of Cu(II) and Cd(II) ions have been determined. It has been shown that Cu(II) and Cd(II) ions at these low concentrations don't influence on the temperature stability of membrane, nuclear and cytoplasm proteins. It has been shown that Cu(II) ions cause an additional condensation of the heterochromatin, and Cd(II) ions cause decondensation of heterochromatin and its partial denaturation.
[The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats].
Zakutskiĭ AN, Chalisova NI, Ryzhak GA, Aniskina AI, Filippov SV, et al. — 2006
The synthetic peptides--cardiogen, bronchogen, prostamax and pancragen were used to investigate their effect on organotypic tissue culture of explants from heart, lungs, prostatic gland and pancreas of young (3-week old) and aged (18-month old) rats. The peptide effective concentration of 0.05 ng/ml showed a stimulating effect in appropriate tissue cultures as compared to the control explants in all groups of rats. So these bioregulatory peptides can be used in clinic practice for the stimulation of reparative processes in the appropriate tissues while ageing.
[The influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ].
Meskhi T, Khachidze D, Barbakadze Sh, Madzhagaladze G, Gorgoshidze M, et al. — 2004
It was shown that chromatin contained in human lymphocytes has two stages of denaturation: with T(d)VII = 94.4 degrees C, Q(d)VII = 50.8 J/g DNA, and T(d)VIII = 105.1 degrees C Q(d)VIII = 44.9 J/g DNA. The peptide bioregulator prostamax causes a redistribution of heat among endotherms T(d)III and T(d)IV and a shift of both endotherms to low temperatures by 2.9 and 1.0 degrees C, respectively. It was supposed that the redistribution of heat among endotherms is connected with a partial relaxation of the 30-nm-thick fiber in the 10-nm filament. A weak decrease in T(d)VIII and T(d)VII of lymphocytes treated with prostamax compared to untreated ones is connected with small structural changes of nucleosomal organization in the 10-nm filament and 30-nm-thick fiber.